New Uses for Pre-existing Approved Drugs
Clinical Trials for 3 Diseases
Algernon Pharmaceuticals has discovered new uses for a number of approved drugs for billion dollar global disease markets. Planning has begun for multiple phase II clinical trials for 3 target diseases.
Algernon Pharmaceuticals is a clinical stage pharmaceutical development company focused on the areas of non–alcoholic steatohepatitis (NASH), chronic kidney disease (CKD) and inflammatory bowel disease (IBD). Algernon’s key compounds were identified using a drug repurposing strategy.
Drug repurposing is the process of discovering new therapeutic uses for existing drugs. Repurposing offers several benefits over traditional drug development including a reduction in investment and risk, shorter research periods and a longer active patent life.
Saving Time and Money
A Drug Repurposing Strategy Can Save up to 8 years of Pre-Clinical Research and Multi Millions in R&D Costs.
The Company’s early research identified number of drug candidates that had already been approved for other diseases. Only drugs that were approved in Russia, Ukraine and Japan were chosen to avoid off-label prescription writing in US & Europe. Off label prescription writing can often interfere with the normal economic pricing models of newly approved drug treatments.
11 drug candidates were initially screened in globally accepted in vivo animal models for 3 new disease areas:
- Non-alcoholic Steatohepatitis (NASH)
- Chronic Kidney Disease (“CKD”)
- Inflammatory Bowel Disease (IBD)
Initial studies showed that a number of the 11 drug candidates either performed equal to or better than the positive controls in each of the animal studies. Subsequent in vivo studies have confirmed their efficacy and as a result, Algernon is now in the planning stages to move its 3 lead compounds into Phase IIa clinical trials.
All Algernon research studies were conducted by 3rd party contract research organizations. The studies were well designed with proper positive controls, usually the currently accepted gold standard for treatment in the disease being screened.
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